The University Area Commission is bounded on the north by the centerline of Glen Echo Ravine, on the east by the centerline of the railroad right-of-way immediately east of Indianola Avenue, on south by the centerline of Fifth Avenue, and on the west by the Olentangy River, with each line extended as necessary so as to intersect with adjacent boundaries.
The four districts are delineated as follows:
- North of 16th Avenue and east of High Street, except that which is part of District 2.
- North of Woodruff Avenue and west of High Street, and a portion east of High Street, west of Indianola, south of Arcadia, and north of Patterson.
- South of 16th Avenue and east of High Street.
- South of Woodruff Avenue and west of High Street.